INTEGRATIVE MULTI-OMICS ANALYSIS DEPICTS THE METHYLOME AND HYDROXYMETHYLOME IN RECURRENT BLADDER CANCERS AND IDENTIFIES BIOMARKERS FOR PREDICTING PD-L1 EXPRESSION

Abstract Background Urinary bladder cancer (UBC) is a common malignancy of the urinary tract; however, the mechanism underlying its high recurrence and responses to immunotherapy remains unclear, making clinical outcome predictions difficult.Epigenetic alterations, especially DNA methylation, play important roles in 5 Piece Full Upholstered Bedroom

The traditional networked radar power allocation is typically optimized with a given jamming model, while the jammer resource allocation is optimized with a given radar power allocation method; such research lack gaming and interaction.Given the rising seriousness of combat scenarios in which radars and jammers compete, this study suggests a deep g

To evaluate the possibilities for biofuel and bioenergy production Acacia Holosericea, which is an invasive plant available in Brunei Darussalam, was investigated.Proximate analysis of Acacia Holosericea shows that the moisture content, volatile matters, fixed carbon, and ash contents King Canopy Bed were 9.56%, 65.12%, 21.21%, and 3.91%, respectiv

Floral scent is likely important to the pollination of parasitic plants, despite that it has not been well-studied.We studied the pollination ecology of the North American stem holoparasite Pilostyles thurberi (Apodanthaceae) at two field sites in Texas.To identify effective pollinators, we collected floral visitors to P.thurberi flowers, observed

Tap water treated in air with low-temperature and low-pressure glow plasma of low frequency was tested for its either stimulation or inhibition of the growth of the selected microorganisms commonly colonizing human organism.The growth of chosen microorganisms was monitored by estimation of optical density of their colonies.The fairly linear growth